Microphysiological Systems for Dissection of Host - Microbiota Interaction, Disease Modelling and Drug Screening 

Publications

Schicke E, Cseresnyés Z, Rennert K, Vau V, Haupt KF, Hornung F, Nietzsche S, Swiczak F, Schmidtke M, Glück B, Koch M, Schacke M, Heller R, Mosig AS, Figge MT, Ehrhardt C, Löffler B, Deinhardt-Emmer S.; Staphylococcus aureus lung infection results in down-regulation of Surfactant Protein-A mainly caused by pro-inflammatory macrophages., Microorganisms, 2020, 8(4), 577 

Spengler K, Kryeziu N, Große S, Mosig AS, Heller R, VEGF Triggers Transient Induction of Autophagy in Endothelial Cells via AMPKα1. Cells, 2020, 9(3), 687

Deinhardt-Emmer S, Rennert K, Schicke E, Cseresnyes Z, Windolph M, Nietzsche S, Heller R, Swiczak F,  Haupt KF, Carlstedt S, Schacke M, Figge MT, Ehrhardt C, Löffler B, Mosig AS; Co-infection with Staphylococcus aureus after primary influenza virus infection leads to damage of the endothelium in a human alveolus-on-a-chip model. Biofabrication, 2020; 12(2):025012. Published 2020 Feb 19

Schubert M, Becher S, Wallert M, Maeβ MB, Abhari M, Rennert K,  Mosig AS, Groβe S, Heller R, Grün M, Lorkowski S; The PPARγ antagonist 2-chloro-5-nitro-N-phenylbenzamide (GW9662) triggers PLIN2 expression via PPARδ and induces lipogenesis and triglyceride accumulation in human THP-1 macrophages. Mol Pharmacol. 2020, Dec 23.

Graf K, Last A, Gratz R, Allert S, Linde S, Westermann M, Gröger M, Mosig AS, Gresnigt MS, Hube B; Keeping Candida commensal - How lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model. Disease Models & Mechanisms, 2019, Sep 12, 12(9)

Maurer M., Gresnigt M.S., Last A., Wollny T., Berlinghof F., Pospich R., Cseresnyes Z., Medyukhina A., Graf K., Gröger M., Raasch M., Siwczak F., Nietzsche S., Jacobsen I.D., Figge M.T., Hube B., Huber O., Mosig A.S.; A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studiesBiomaterials, 2019, 220, November 2019, 119396

Blaurock-Möller N., Gröger M., Siwczak F., Dinger J., Schmerler D., Mosig A.S.*, Kiehntopf M.* (* shared senior authorship); CAAP48, a new sepsis biomarker, induces hepatic dysfunction in an in vitro liver-on-chip model. Frontiers in Immunology, 2019, Feb 25;10:273. doi: 10.3389/fimmu.2019.00273 

Leonhardt J., Große S., Marx C., Siwczak F., Stengel S., Bruns T., Bauer R., Kiehntopf M., Williams DL., Wang Z.Q., Mosig A.S., Weis S., Bauer M., Heller R; Candida  albicans  β‐glucan  differentiateshuman  monocytes  into a  specific  subset of  macrophages. Frontiers in Immunology, 2018, Nov 30;9:2818-2831. doi: 10.3389/fimmu.2018.02818 

Pein H., Ville A., Pace S., Temml V., Garscha U., Raasch M., Alsabil K., Viault G., Dinh CH., Guilet D., Troisi F., Neukirch K., König S., Bilancia R., Waltenberger B., Stuppner H., Wallert M., Lorkowski S., Weinigel C., Rummler S., Birringer M., Roviezzo F., Sautebin L., Helesbeux J.J., Séraphin D., Mosig A.S., Schuster D.,  Rossi A., Richomme P., Werz O., Koeberle A.; Endogenous metabolites of vitamin E limit inflammation by targeting 5‑lipoxygenase. Nature Communications, 2018, 9(1):3834 –3851 

Raasch M., Fritsche E., Kurtz, A., Bauer M., Mosig A.S.; Microphysiological systems meet hiPSC technology - new tools for disease modeling of liver infections in basic research and drug development. Advanced Drug Delivery Reviews, 2018, Jun 15, pii: S0169-409X(18)30147-9

Ryabchykov O., Bräutigam K., Galler K., Neugebauer U., Mosig A.S., Bocklitz T., Popp J; Characterization of the unique human liver cell line HepaRG by Raman microspectroscopy. Journal of Raman Spectroscopy, 2018, 49: 935-942 

Heinze K., Kritsch D., Mosig A.S., Dürst M., Häfner N., Runnebaum I.B.; Functional analyses of RUNX3 and CaMKIINα in ovarian cancer cell lines reveal tumor-suppressive functions for CaMKIINα and dichotomous roles for RUNX3 transcript variants. International Journal of Molecular Sciences, 2018, Jan 15;19(1):253-271 

Gröger M., Dinger J., Kiehntopf M., Peters F.T., Rauen U., Mosig A.S.; Preservation of Cell Structure, Metabolism and Biotransformation Activity of Liver-on-chip Organ Models by Hypothermic Storage. Advanced Healthcare Materials, 2017, Jan;7(2): 1700616-1700630 

Fahrner R., Möller A., Press AT., Kortgen A., Kiehntopf M.D., Rauchfuss F., Settmacher U., Mosig A.S.; Short-term treatment with taurolidine is associated with liver injury. BMC Pharmacology and Toxicology, 2017, 18(1):61-70 

Rennert K., Nitschke M., Wallert M., Keune N., Raasch M., Lorkowski S., Mosig A.S.; Thermo-responsive cell culture carrier – effects on macrophage functionality and detachment efficiency. Journal of Tissue Engineering, 2017, 25 (8):1-7 28 

Kritsch D., Hoffmann F., Steinbach D., Jansen L., Mary S., Mosig A.S., Sonnemann J., Peters S., Thomale J., Dürst M., Runnebaum I., Häfner, N.; Tribbles 2 mediates cisplatin sensitivity and DNA damage response in epithelial ovarian cancer. International Journal of Cancer, 2017 Jul 3: 1600-1614 

Mann A., Pelz T., Rennert K., Mosig A.S., Decker M., Lupp A.; Evaluation of HepaRG cells for the assessment of indirect drug-induced hepatotoxicity using INH as a model substance. Human Cell, 2017 May 19:267-278 

Thomas L., Rao Z., Gerstmeier J., Raasch M., Weinigel C., Rummler S., Menche D., Müller R., Pergola C., Mosig A.S., Werz O.; Selective upregulation of TNFα expression in classically-activated human monocyte-derived macrophages (M1) through pharmacological interference with V-ATPase. Biochemical Pharmacology, 2017, 130:71-82 

Pergola C, Schubert K, Pace S, Ziereisen J, Nikels F, Scherer O., Hüttel S., Zahler S., Vollmar A., Weinigel C., Rummler S., Muller R., Raasch M., Mosig A.S., Koeberle A., Werz O.; Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy. Scientific Reports, 2017, 7:41434-41446 

Schüler R., Osterhoff M.A., Frahnow T., Seltmann A.C., Busjahn A., Kabisch S., Xu L., Mosig A.S., Spranger J., Möhlig M., Hornemann S., Kruse M., Pfeiffer A.F.H.; High saturated fat diet increases circulating angiotensin converting enzyme which is enhanced by the rs4343 polymorphism defining persons at risk of nutrient dependent increases of blood pressure. Journal of American Heart Association (JAHA), 2017, 6(1): 4465-4476 

Gröger M,. Lange M., Rennert K., Kaschowitz T., Plettenberg H., Hoffmann M., Mosig A.S.; Novel approach for the prediction of cell densities and viability in standardized translucent cell culture biochips with near infrared spectroscopy. Engineering in Life Sciences, 2017, 17 5 May: 585-593

Englert C., Trützschler A.K., Raasch M., Bus T., Borchers P., Mosig A.S.*, Träger A.*, Schubert U.S.* (* shared senior authorship); Crossing the blood-brain barrier: Glutathione-conjugated poly(ethylene imine) for gene delivery. Journal of Controlled Release, 2016, 30 (241):1-14. (* shared senior authorship)

Raasch M., Rennert K., Jahn T., Gärtner C., Schönfelder G., Huber O., Seiler AEM., Mosig A.S.; An integrative microfluidically supported in vitro model of an endothelial barrier combined with cortical spheroids simulates effects of neuroinflammation in neocortex development. Biomicrofluidics, 2016, 10(4): 44102 – 441016 

Rennert K, Heisig K, Groeger M, Wallert M, Funke H, Lorkowski S, Huber O, Mosig A.S; Recruitment of CD16+ monocytes to endothelial cells in response to LPS-treatment and concomitant TNF release is regulated by CX3CR1 and interfered by soluble fractalkine. Cytokine, 2016, 83: 41–52 

Gröger M., Rennert K., Giszas B., Weiß E., Dinger J., Funke H., Kiehntopf M., Peters F.T., Lupp A., Bauer M., Claus RA., Huber O., Mosig AS.; Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model. Scientific Reports, 2016, 6: 21868 - 21884

Rennert K., Otto P., Funke H., Huber O., Tomaso H., Mosig A.S.; A human macrophage - hepatocyte co-culture model for comparative studies of infection and replication of Francisella tularensis LVS strain and subspecies holarctica and mediasiatica. BMC Microbiology, 2016,16(1):2-12 

Press AT., Ungelenk L., Rinkenauer A.C., Gröger M., Lehmann FD., Mosig A.S., Schubert US., Clemens, MG., Bauer M.; A new fluorescent dye for cell tracing and mitochondrial imaging in vitro and in vivo. Journal of Biophotonics, 2016, 9(9):888-900 

Rennert K., Steinborn S., Gröger M., Ungerböck B., Jank A.M., Ehgartner J., Nietzsche S., Dinger J., Kiehntopf M., Funke H., Peters F.T., Lupp A., Gärtner C., Mayr T., Bauer M., Huber O., Mosig A.S; A microfluidically perfused three dimensional human liver model. Biomaterials, 2015, 71:119-131 

Gögebakan Ö., Osterhoff M.A., Schüler R., Pivovarova O., Kruse M., Seltmann A.C., Mosig A.S., Rudovich N., Nauck M., Pfeiffer A.F.; GIP increases adipose tissue expression and blood levels of MCP-1 in humans and links high energy diets to inflammation: a randomised trial. Diabetologia, 2015, 58(8):1759-68 

Rinkenauer A.C., Press A.T., Raasch M., Pietsch C., Schweizer S., Schwörer S., Rudolph K.L., Mosig A.S., Bauer M., Traeger A., Schubert U.S.; Comparison of the uptake of methacrylate-based nanoparticles in static and dynamic in vitro systems as well as in vivo. Journal of Controlled Release, 2015, 216:158-68 

Maeß M., Keller A.A., Rennert K., Mosig A.S., Lorkowski S.; Optimization of the transfection of human THP-1 macrophages by application of Nunc UpCell technology. Analytical Biochemistry, 2015, 479:40-42 

Raasch M., Rennert K., Jahn T., Peters S., Henkel T., Huber O., Schulz I., Becker H., Lorkowski S., Funke H., Mosig A.S.; Microfluidically supported biochip design for culture of endothelial cell layers with improved perfusion conditions. Biofabrication, 2014, 7(1):15013-15026 

Press A.T., Traeger A., Pietsch C., Mosig A.S., Wagner M., Clemens M.G., Jbeily N., Koch N., Gottschaldt M., Bézière N., Ermolayev V., Ntziachristos V., Popp J., Kessels M., Qualmann B., Schubert U.S., Bauer M; Cell type-specific delivery of short interfering RNAs by dye-functionalized "theranostic“ nanoparticles. Nature Communications, 2014, 5:5565-5578 

Wallert M., Mosig A.S., Rennert K., Funke H., Ristow M., Pellegrino R.M., Cruciani G., Galli F., Lorkowski S., Birringer M.; Long-chain metabolites of α-tocopherol occur in human serum and inhibit macrophage foam cell formation in vitro. Free Radical Biology & Medicine, 2013, 68:43-51

Liesenfeld M., Mosig A.S., Funke H., Jansen L., Runnebaum I.B., Durst M., Backsch C.; SORBS2 and TLR3 induce premature senescence in primary human fibroblasts and keratinocytes. BMC Cancer, 2013, 13(1): 507-518 

Lange M., Engelhardt S., Liebold S., Plettenberg H., Mosig A.S., Hoffmann M.; Analysis of glucose and fetal calf serum in aqueous solution for Multi Organ Tissue Flow (MOTiF) bioreactors using NIR Spectroscopy. Biomedical Engineering 2013, Sep 7:1-2 

Pottgiesser T., Schumacher Y.O., Funke H., Rennert K., Baumstark M.W., Neunuebel K., Mosig A.S.; Gene expression in the detection of autologous blood transfusion in sports - a pilot study. Vox Sanguinis, 2009, 96(4):333-336 

Mosig A.S., Rennert K., Krause S., Kzhyshkowska J., Neunubel K., Heller R., Funke H.; Different functions of monocyte subsets in familial hypercholesterolemia: potential function of CD14+ CD16+ monocytes in detoxification of oxidized LDL. FASEB Journal, 2009, 23(3): 866-874 

Mosig A.S., Rennert K., Buttner P., Krause S., Lutjohann D., Soufi M., Heller R., Funke H.; Monocytes of patients with familial hypercholesterolemia show alterations in cholesterol metabolism. BMC Medical Genomics, 2008, 1: 60-72 

Büttner P., Mosig A.S., Funke H.; Gene expression profiles of T lymphocytes are sensitive to the influence of heavy smoking: A pilot study. Immunogenetics, 2007, 59(1):37-43 

Büttner P., Mosig S., Lechtermann A., Funke H., Mooren FC; Exercise affects the gene expression profiles of human white blood cells. Journal of Applied Physiology, 2007, 102(1):26-36