Microphysiological Systems in Biomedical Research: Immunology, Human Stem Cells, Microbiota Host - Interaction, Disease Modeling and Drug Development 


Alexander's CV

Research interests

Host-Microbiota / Host-Pathogen interaction; Stem cells; Immune response; Macrophage biology; organ-on-a-chip / microphysiological systems


2017    Venia legendi (Priv. Doz.) in Biochemistry and Cell Biology

2017    Habilitation in Biochemistry and Cell Biology (Dr. med. habil.) Thesis “Microphysiological Systems of Liver and Blood-Brain-Barrier”

2007    PhD (Dr. rer. nat.) Thesis „Investigation of Atherosclerotic Processes in Circulating Monocytes and T-Cells of Patients with Familial Hypercholesterolemia“

2002    Diploma in Biochemistry and Molecular Biology (Dipl. Biochem.)

Professional Appointments

Since 2018    Co-Founder Dynamic42 GmbH (Spin off from Jena University Hospital)
Since 2017    Co-Lead Animal Labs and Replacement Methods
Since 2015    Elected member of the Board of Directors of the CSCC
Since 2015    Head of Research Group INSPIRE – In Vitro Sepsis Research, Center for Sepsis Control and Care


Research Award of the BMEL for Replacement of Animal Experimentation in Infection Research (2017); Innovation Award of the BioRegions (2016); Animal welfare award of the State of Thuringia, (2014)

Project management

BMBF (ImmunAVATAR, PI, Coordinator), European Commission - MARIE SKLODOWSKA-CURIE ACTIONS, Innovative Training Networks (ITN) for advancing Organ-on-a-chip technology in Europe (EUROoC, PI); European Commission - Immune Safety Avatar - non clinical mimicking of the immune system effects of immunomodulatory therapies (imSAVAR), Fundação para a Ciência e a Tecnologia / “la Caixa” Banking Foundation (TRANS-CPA, Co-PI); DFG (MARLIN, PI); DFG CRC Polytarget (PI), DFG Priority Program "Physics of Parasitism", PI; DFG Excellence Cluster “Balance of the Microverse” (MicroGut, PI; cholera-on-chip, PI); Leibniz Research Society: Quantitative monitoring of tailored therapy against bacterial super-infection in viral pneumonia by spatiotemporal microscopy in a lung-on-chip model (PNEUTHERA)