Microphysiological Systems in Biomedical Research: Immunology, Human Stem Cells, Microbiota Host - Interaction, Disease Modeling and Drug Development 

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Our Research Group develops microphysiological systems emulating human organ function in vitro.

We are focused on the investigation of mechanisms of human host-microbiota interaction, in particular on the orchestration of the immune response to commensal and pathogenic microorganisms.

We work in a interdisciplinary research area including microbiology, immunology, cell biology and bioengineering to evolve advanced microfluidic organ-on-chip platforms for studies on maintenance of tissue homeostasis, inflammatory disease mechanisms and the immune safety testing of drugs. Advanced tissue engineering strategies developed by our group aiming to recreate human organ models based on primary cells and human stem cells.The models are used in biomedical research as alternative to animal testing.

Our infrastructure includes fully equipped biosafety level 2 category laboratories for cell culture, tissue engineering and molecular biology. The group has access to 180 m2 lab space equipped with flow cytometry, mass spectrometry, HPLC, qPCR etc. s equipped for cell isolation, work with microorganisms, stem cells and primary cell material. An advanced microfluidic platform for operation of for organ-on-chip culture under precisely controlled environmental conditions is available.